Paper on origins of CLL published!

The origins of MBL and CLL remain elusive. Using mitochondrial genetics and epigenetic/transcriptional profiling at the single cell level, we trace these roots in a cohort of 24 individuals. Finally published in Genome Biology.

Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia

Anja C. Rathgeber, Stacey M. Fernandes, Adi Nagler, Shuqiang Li, David M. Dorfman, ..., Jennifer R. Brown, Kenneth J. Livak, Leif S. Ludwig, Catherine J. Wu, Livius Penter

Genome Biology   ·   15 Apr 2026   ·   doi:10.1186/s13059-026-04072-4

CLL initiation at the single cell level

lymphoma single cell genomics mitochondrial DNA mutations